Clinical Chemistry Podcast

Transdermal GFR Signals a New Horizon in Renal Diagnostics

Vrajesh Pandya. Transdermal GFR Signals a New Horizon in Renal Diagnostics. Clinical Chemistry, Volume 71, Issue 12, December 2025, Pages 1281–1282. https://doi.org/10.1093/clinchem/hvaf106

Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol

Jeffrey W Meeusen, Xin Yi, Steven W Cotten, Jacob B Nielsen, Leslie J Donato, Patricia M Jones, Alagar R Muthukumar, Rafael Zubirán, Alan T Remaley, Jing Cao, Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1138–1146, https://doi.org/10.1093/clinchem/hvaf099

Audio Summary December 2025

Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use

Ruben Y Luo, Priscilla S W Yeung, Morgan W Mann, Lichao Zhang, Yifei K Yang, Andrew N Hoofnagle, Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1111–1124, https://doi.org/10.1093/clinchem/hvaf094

Embracing Generative Artificial Intelligence as a Support Tool for Clinical Decision-Making

Nicholas C Spies, Embracing Generative Artificial Intelligence as a Support Tool for Clinical Decision-Making, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1178–1179, https://doi.org/10.1093/clinchem/hvaf084

Diagnostic Value of Digital Estimates of Trophoblastic Mosaicism in Genome-Wide Cell-Free Fetal DNA Screening

Risk vs Prevalence: Weighing Routine DPYD Variant Testing Prior to Fluoropyrimidine-Based Chemotherapy

Audio Summary November 2025

Optimizing Estimation: Perspective on Drug Dosing Using New CKD-EPI Equations

Audio Summary October 2025

Utilizing the Stability of Individual Homeostatic Setpoints over Time - A Step Forward on the Path to Personalized Laboratory Medicine

Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic

Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis

Toward Improved Prostate Cancer Screening: Insights from the Göteborg-2 Trial

Audio Summary September 2025

Proteomic Aging Clock Predicts Mortality and Risk of Common Age-Related Diseases

Influence of Macrotroponin on the 99th Percentile Threshold in 2 High-Sensitivity Cardiac Troponin Assays

Pulse Oximeter Performance across Populations with Diverse Skin Tones

Polygenic Effects on Hb A1c May Mask Hyperglycemia and Increase Retinopathy Risk

Audio Summary August 2025

Reducing the Noise in Plasma Metagenomics to Further Define Clinical Utility

Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma

Audio Summary July 2025

Robotic Process Automation in Laboratory Medicine

HOPEing That a PEACEful Resolution for the Clinical Utility of High-Sensitivity Cardiac Troponin in the Ambulatory Setting Will Improve Laboratory Testing

Audio Summary June 2025

The Slow Progress in Developing Better Long-Term Cardiovascular Risk Assessment in Women Continues

Pediatric vaccine-induced antibody thresholds: Rethinking pre-immunosuppression serologic testing and revaccination implications

Reevaluating the threshold for low total testosterone

Help Us to Help You: Recommendations for Continued Enforcement Discretion for Common Infectious Disease Test Modifications under the FDA Final Rule