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<p>Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in this week's podcast.</p> <p><em>This podcast is intended for healthcare professionals only</em>.</p> <p>To read a partial transcript or to comment, visit:</p> <p>https://www.medscape.com/twic</p> <p><strong>I Listener Feedback</strong></p> <ul> <li><strong>Complete Revascularization for Acute MI Meta-analysis https://doi.org/10.1016/S0140-6736(25)02170-1</strong></li> </ul> <p><strong>II A Sea Change in the Treatment of Carotid Artery Disease — CREST-2 Published</strong></p> <ul> <li><strong>ECST-2 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00107-3/fulltext</strong></li> <li><strong>SPACE-2 https://pubmed.ncbi.nlm.nih.gov/36115360/</strong></li> <li><strong>CREST-2 Trial www.nejm.org/doi/full/10.1056/NEJMoa2508800</strong></li> <li><strong>CREST Protocol paper https:...