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<p>GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John Mandrola, MD, discusses in this week's podcast.</p> <p><em>This podcast is intended for healthcare professionals only</em>.</p> <p>To read a partial transcript or to comment, visit:</p> <p>https://www.medscape.com/twic</p> <p><strong>I. Listener Feedback</strong></p> <p><strong>HYPERION trial https://www.nejm.org/doi/10.1056/NEJMoa2508170</strong></p> <p><strong>ZENITH trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415160</strong></p> <p><strong>II GLP1 Use in HFrEF</strong></p> <p><strong>Effects of GLP-1s in Patients With HFrEF https://doi.org/10.1016/j.jchf.2025.102573</strong></p> <p><strong>FIGHT Study https://jamanetwork.com/journals/jama/fullarticle/2540402</strong></p> <p><strong>FIGHT Study Post-hoc Analysis https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14...