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<p>Rose Byrne has taken many forms on-screen. In Mary Bronstein’s new film <a href="https://www.fandango.com/if-i-had-legs-id-kick-you-2025-241791/movie-overview"><em>If I Had Legs I’d Kick You</em></a>, she delivers a career-defining performance as a Long Island therapist and mother slowly unraveling under the weight of her child’s mysterious illness.</p> <p> </p> <p>We begin by discussing the maternal madness at the heart of this new film from A24 (6:30), the long, collaborative road to shaping the character (10:00), and what it was like to have Conan O’Brien as a scene partner (13:30). Then, Byrne reflects on her debut performance in <em>Dallas Doll</em> (19:45), the plays and poems that inspired her as a teenager (22:30), and a formative role in the cult classic <em>Two Hands, </em>opposite the late Heath Ledger (26:00).</p> <p> </p> <p>In the back half, we unpack the sexism she faced in Hollywood in the aughts (32:40), her unexpected comedic break...