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<p>On December 4, 2025 we talked with Dr. Mike Beckstead about his work on changes in dopaminergic neuron excitability in the ventral tegmental area in an animal model of Alzheimer's disease. Mike explained the molecular mechanism of the excitability change and the change in gene expression at its cause.</p><p>Guest: </p><p>Mike Beckstead, Professor and Hille Family Foundation Chair in Neurodegenerative Disease Research, Aging & Metabolism Research Program Oklahoma Medical Research Foundation</p><p>Participating:</p><p>Matt Wanat, Department of Neuroscience, Developmental and Regenerative Biology, UTSA</p><p>Host:</p><p>Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UTSA</p><p>Thanks to James Tepper for original music</p><p><br /></p>