Fibrodysplasia Ossificans Progressiva: Mechanism of Disease

<p>Fibrodysplasia ossificans progressiva (FOP) is a severely disabling myopathy in which extraskeletal bone forms and accumulates over time within muscles and soft tissues.^1,2 Here’s what we know so far about the mechanisms of heterotopic ossification in patients with FOP.</p> <p><strong><span data-teams="true">References:</span></strong></p> <ol> <li><span data-teams="true">Kaplan FS et al. <i>Best Pract Res Clin Rheumatol</i> 2008;22:191–205.</span></li> <li><span data-teams="true">Pignolo</span><span data-teams="true"> RJ et al. <i>Orphanet J Rare Dis</i> 2011;6:80.</span></li> </ol> <p style="text-align: right;">© 2025 Ipsen Biopharmaceuticals Inc. All rights reserved. ALLSC-US-001927 | August 2025</p>