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<p>This episode: A bacteriophage that overcomes the bacterial CRISPR/Cas immune system by interrupting the CRISPR DNA with its own genome!</p> <p><span style="font-size: medium;"><a href= "http://traffic.libsyn.com/bacteriofiles/BF473.mp3">Download Episode</a></span> (6.8 MB, 10 minutes)<br /> <br /> <span style="font-weight: bold;">Show notes:</span><br /> Microbe of the episode: Wenzhou mammarenavirus</p> <div> <div> <div><strong>Takeaways</strong></div> <div> <div>Bacteria have many ways to resist being exploited by bacteriophage viruses, including the adaptable CRISPR/Cas system that uses a piece of viral nucleic acid sequence to target and destroy incoming phages. But phages also have many ways to evade and disrupt bacterial defenses.<br /> <br /> In this study, a phage is discovered that inserts its own genome into the CRISPR/Cas sequence in the bacterial genome, disrupting the bacterial defenses. To escape the defenses while it is doing this insertion, it carries genes for previ...