EP 199: Functional genomics at scale: Using in vivo perturbations to study genetic risk variants in the brain with Xin Jin of Scripps Research Institute

<p>This week on The Genetics Podcast, Patrick is joined by Xin Jin, Associate Professor in the Department of Neuroscience at The Scripps Research Institute. They discuss how <em>in vivo</em> Perturb-seq enables scalable and high-resolution modeling of neurogenetic disorders like autism, how introducing mutations directly into living mouse brains reveals cell-type vulnerabilities and convergent pathways, and why this approach could transform therapeutic development by identifying shared mechanisms across diverse genetic mutations.</p><p><br></p><p><strong>Show Notes: </strong></p><p><strong>0:00 </strong>Intro to The Genetics Podcast</p><p><strong>00:58</strong> Welcome to Xin </p><p><strong>01:52</strong> Overview of <em>in vivo </em>Perturb-seq</p><p><strong>05:10 </strong>Identifying <em>de novo </em>variants in autism spectrum disorder</p><p><strong>09:00</strong> Using perturbations to map how autism-linked mutations affect specific brain cell types</p><p><strong>13:04 </strong>App...