Loxapine Pharmacology

<p>Loxapine is a first-generation (typical) antipsychotic with dopamine D2 receptor antagonism as its primary mechanism, though it also has affinity for serotonin 5-HT2A receptors, making its pharmacology somewhat atypical.</p> <p>Loxapine is available in multiple formulations, including oral capsules and an inhalation powder, the latter approved specifically for acute agitation in patients with schizophrenia or bipolar I disorder.</p> <p>Sedation and extrapyramidal symptoms (EPS), including dystonia, akathisia, and parkinsonism, are common adverse effects due to its potent dopamine blockade in the nigrostriatal pathway.</p> <p>Orthostatic hypotension can occur with loxapine due to its alpha-1 adrenergic blockade, requiring monitoring in elderly patients or those on antihypertensives.</p> <p class="has-vivid-red-color has-text-color">Be sure to check out our free Top 200 study guide &#8211; <a href="https://www.reallifepharmacology.com/100-free-pharmacology-test/">a 31 page PDF that is...