Nifedipine Pharmacology

<p>Nifedipine is a dihydropyridine calcium channel blocker that selectively inhibits L-type calcium channels in vascular smooth muscle, leading to vasodilation and reduced peripheral vascular resistance.</p> <p>The extended-release formulation of nifedipine provides more stable plasma concentrations and is preferred for chronic management of hypertension and angina.</p> <p>Common adverse effects include headache, flushing, peripheral edema, and dizziness, all related to its vasodilatory action.</p> <p>Nifedipine undergoes extensive first-pass metabolism in the liver, primarily via CYP3A4 enzymes, which significantly influences its bioavailability and potential drug interactions.</p> <p>CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, grapefruit juice) can increase plasma levels of nifedipine, raising the risk of hypotension and adverse effects.</p> <p class="has-vivid-red-color has-text-color">Be sure to check out our free Top 200 study guide &#8211; <a href="https://www.reallifeph...