Evolution designed us to die fast; we can change that — Jacob Kimmel

<p><a target="_blank" href="https://x.com/jacobkimmel">Jacob Kimmel</a> thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacob’s controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him.</p><p>Watch on <a target="_blank" href="https://www.youtube.com/watch?v=XCLODgdCmKA">YouTube</a>; listen on <a target="_blank" href="https://podcasts.apple.com/us/podcast/evolution-designed-us-to-die-fast-we-can-change-that/id1516093381?i=1000722975425">Apple Podcasts</a> or <a target="_blank" href="https://open.spotify.com/episode/3xUwUYLpjGI3bxsEM1...